Here, the authors show that delivery of larger sets of neo-antigens using an adenovirus-based vaccination platform, results in much better tumor protection when combined with checkpoint blockade in a mouse model of advanced disease. Article open 19 Jun Nature Communications. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model. Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr — the putative receptor for soluble IgM — is a potent negative regulator of anti-tumour immunity.
Article open 18 Jun Nature Communications. Chimeric antigen receptor CAR T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, resulting in diminished CAR-T cells toxicity and enhanced solid tumor eradication. The natural product nimbolide covalently reacts with a functional cysteine of the E3 ubiquitin ligase RNF, resulting in impaired substrate recognition and degradation, enabling the use of nimbolide for targeted protein degradation.
Article 17 Jun Nature Chemical Biology. Article 17 Jun Nature Genetics. Article 17 Jun Nature Biomedical Engineering. Analysis of evolutionary dynamics of colorectal cancers and paired distant brain or liver metastases provides evidence that early disseminated cancer cells seed metastases before the carcinoma is clinically detectable.
Letter 17 Jun Nature. Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.
Article open 17 Jun Nature Communications. Tobias Ackermann et al. This study identifies LIP as a regulator of metabolic reprogramming that is reminiscent of cancer metabolism. Article open 14 Jun Communications Biology. Despite their promise, immunotherapy—radiotherapy combinations could be limited by the patient-specific nature of radiation-induced immune responses. This Review discusses methods of assessing the immune response to radiotherapy and approaches to predict the synergy between immunotherapy and radiotherapy for personalized medicine.
This Review discusses the diverse effects of senescence and the senescence-associated secretory phenotype SASP on tumour growth, focusing on the functional and sometimes opposing outputs of the SASP in stromal cells and incipient tumour cells. In this Review of adult diffuse gliomas, Molinaro et al.
Therapeutic strategies in malignant melanoma are challenged by resistance mechanisms that are based on phenotype plasticity. This Review discusses different phenotypes in melanoma, how they are controlled and how phenotype plasticity contributes to melanoma progression and therapy resistance. It also outlines the potential for manipulating their functions for use as an unconventional form of cancer immunotherapy.
Increasing evidence suggests that patients undergoing trimodality bladder-preserving treatment TMT and radical cystectomy have comparable outcomes but many continue to be offered surgery. This Review discusses the development of TMT and highlights how technological and biological advances could inform personalized treatment strategies.
The authors of this Review discuss treatments currently available for patients with head and neck squamous cell carcinomas focusing in those of the oral cavity, oropharynx, hypopharynx and larynx. Advances in surgical and non-surgical approaches mainly combinations of radiotherapy and chemotherapy are discussed, including the first immunotherapeutic agents approved for these malignancies. Bispecific antibodies — a large family of molecules that are designed to recognize two different epitopes or antigens — come in many formats and can have the potential for novel functionalities that are not provided by mixtures of monoclonal antibodies.
This article reviews the current bispecific antibody landscape from a mechanistic perspective, including a comprehensive overview of the pipeline. Neutrophils accumulate in the circulation of patients with cancer, and the neutrophil-to-lymphocyte ratio is a widely used biomarker. However, the effects of neutrophils on tumour development and progression, and the efficacy of therapies, remain relatively unknown. In this Review, the authors draw on data from animal models and patients with cancer to provide an overview of the effects of neutrophils in cancer.
The authors present a high-throughput single-cell ChIP-seq method with coverage of up to 10, loci per cell. They identify diverse chromatin landscapes in breast cancer cells characterized by dynamic H3K27me3 levels. Technical Report 31 May Nature Genetics. Adrenocortical carcinoma ACC is a rare and aggressive neoplasm that arises in the adrenal gland cortex.
This Review highlights how genomics can be used to stratify ACC and potentially improve clinical care, outcomes and patient quality of life. In this Review, the authors describe emerging data on genetically targeted therapies for patients with DLBCL and how these might improve patient outcomes.
Barrett oesophagus BE is a precursor lesion to oesophageal adenocarcinoma and involves intestinal metaplasia replacement of squamous epithelium with columnar epithelium in response to gastro-oesophageal reflux. This Primer summarizes the latest research about BE, including improvements in treatment and disease management. Treatments that succeeded in one cancer type can be tested against other types. The improved understanding of molecular biology and cellular biology due to cancer research has led to new treatments for cancer since US President Richard Nixon declared the " War on Cancer " in Competition for financial resources appears to have suppressed the creativity, cooperation, risk-taking and original thinking required to make fundamental discoveries, unduly favoring low-risk research into small incremental advancements over riskier, more innovative research.
Other consequences of competition appear to be many studies with dramatic claims whose results cannot be replicated and perverse incentives that encourage grantee institutions to grow without making sufficient investments in their own faculty and facilities. Virotherapy , which uses convert viruses, is being studied. Cancer affects approximately 1 in 1, pregnant women. The most common cancers found during pregnancy are the same as the most common cancers found in non-pregnant women during childbearing ages: breast cancer, cervical cancer, leukemia, lymphoma, melanoma, ovarian cancer and colorectal cancer.
Diagnosing a new cancer in a pregnant woman is difficult, in part because any symptoms are commonly assumed to be a normal discomfort associated with pregnancy.
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As a result, cancer is typically discovered at a somewhat later stage than average. Some imaging procedures, such as MRIs magnetic resonance imaging , CT scans , ultrasounds and mammograms with fetal shielding are considered safe during pregnancy; some others, such as PET scans , are not. Treatment is generally the same as for non-pregnant women. However, radiation and radioactive drugs are normally avoided during pregnancy, especially if the fetal dose might exceed cGy. In some cases, some or all treatments are postponed until after birth if the cancer is diagnosed late in the pregnancy.
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Early deliveries are often used to advance the start of treatment. Surgery is generally safe, but pelvic surgeries during the first trimester may cause miscarriage. Some treatments, especially certain chemotherapy drugs given during the first trimester , increase the risk of birth defects and pregnancy loss spontaneous abortions and stillbirths.
Elective abortions are not required and, for the most common forms and stages of cancer, do not improve the mother's survival. In a few instances, such as advanced uterine cancer, the pregnancy cannot be continued and in others, the patient may end the pregnancy so that she can begin aggressive chemotherapy. Some treatments can interfere with the mother's ability to give birth vaginally or to breastfeed. Radiation to the breast reduces the ability of that breast to produce milk and increases the risk of mastitis.
Also, when chemotherapy is given after birth, many of the drugs appear in breast milk, which could harm the baby. Veterinary oncology , concentrating mainly on cats and dogs, is a growing specialty in wealthy countries and the major forms of human treatment such as surgery and radiotherapy may be offered. The most common types of cancer differ, but the cancer burden seems at least as high in pets as in humans.
Animals, typically rodents, are often used in cancer research and studies of natural cancers in larger animals may benefit research into human cancer. In non-humans, a few types of transmissible cancer have been described, wherein the cancer spreads between animals by transmission of the tumor cells themselves. This phenomenon is seen in dogs with Sticker's sarcoma also known as canine transmissible venereal tumor , and in Tasmanian devils with devil facial tumour disease DFTD.
From Wikipedia, the free encyclopedia. For other uses, see Cancer disambiguation. Play media. Main article: Cancer signs and symptoms. Main article: Metastasis. Main article: Causes of cancer. Further information: Alcohol and cancer and Smoking and cancer. Main article: Diet and cancer. Main article: Infectious causes of cancer. Main article: Radiation-induced cancer. Main article: Cancer syndrome. Main article: Carcinogenesis. Main article: Oncogenomics. Main article: Cancer epigenetics.
Further information: List of cancer types and List of oncology-related terms. Main article: Cancer prevention. Main article: Cancer screening. See also: Cancer syndrome. Main articles: Management of cancer and oncology. Main article: Cancer immunotherapy. Main article: Lasers in cancer treatment.
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Cancer caused by germline mutations is called inherited cancer. Mutations happen often. A mutation may be beneficial, harmful, or neutral. This depends where in the gene the change occurs. Typically, the body corrects most mutations. A single mutation will likely not cause cancer. Usually, cancer occurs from multiple mutations over a lifetime. That is why cancer occurs more often in older people. They have had more opportunities for mutations to build up. When a tumor suppressor gene mutates, cells grow uncontrollably. And they may eventually form a tumor.
They also increase the risk of pancreatic cancer and melanoma in women and men. The most commonly mutated gene in people with cancer is p53 or TP Most p53 gene mutations are acquired.
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Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer. These turn a healthy cell into a cancerous cell. Mutations in these genes are not known to be inherited. HER2, a specialized protein that controls cancer growth and spread. It is found in some cancer cells. For example, breast and ovarian cancer cells. The RAS family of genes, which makes proteins involved in cell communication pathways, cell growth, and cell death. DNA repair genes. These fix mistakes made when DNA is copied.
Many of them function as tumor suppressor genes. If a person has an error in a DNA repair gene, mistakes remain uncorrected. Then, the mistakes become mutations.