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Guide Diet & Health Today - Volume 1

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The term " metabolic syndrome " describes a cluster of health risk factors, including obesity around the waist, insulin resistance , high blood pressure , and dyslipidemia , which refers to high total cholesterol levels or high levels of "bad" cholesterol. Together, these risk factors may compromise a person's cardiometabolic health, putting people at risk of cardiovascular disease and type 2 diabetes. In fact, estimates show that having metabolic syndrome raises the risk of type 2 diabetes by fivefold and the risk of cardiovascular disease by threefold.

Furthermore, studies have found links between metabolic syndrome and various forms of cancer , such as "breast, pancreatic, colon, and liver cancer. Recent studies have shown that the composition of our gut bacteria plays an important role in obesity-related conditions, such as metabolic syndrome, and that tweaking the bacterial balance in our guts by administering specific strains could be a valid avenue for treatment. For instance, a study that Medical News Today reported on in found that A. The study in question was led by Prof.

Willem de Vos, of the University of Wageningen, in the Netherlands. Cani and colleagues — who have been studying the role of Akkermansia in cardiometabolic health since — also showed that "administration of live or pasteurized A.


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However, at the time, the researchers were not able to prove that the bacterium had the same benefits in humans as it did in mice. Now, in a new study in humans, Prof.

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Cani and his team confirm that giving A. The researchers published their findings in the journal Nature Medicine.


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In the current study, the research team gave Akkermansia to participants who were either overweight or obese. The research was a "randomized, double-blind, placebo-controlled pilot study" that enrolled 40 individuals, 32 of whom finished the clinical phase of the study.

International Journal of Food, Nutrition & Public Health

The participants — who had prediabetes and metabolic syndrome — were assigned to three groups: a group that received a placebo , another that received live Akkermansia , and a group that took the pasteurized bacteria as a nutritional supplement. The study lasted for 3 months. The researchers aimed primarily to assess the safety and tolerability of the supplement, as well as its impact on metabolic parameters, such as insulin resistance, circulating lipids, fat around the waistline, and body mass.

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Importantly, people who took the pasteurized bacteria showed improvements in insulin sensitivity and lower cholesterol levels, along with slight reductions in body weight, fat mass, hip circumference, and markers of inflammation in the liver. By contrast, the markers of metabolic health continued to deteriorate in people who took the placebo. Cani and the team conclude:. The research, which was a proof-of-concept study, shows that administering pasteurized Akkermansia to humans as a dietary supplement reduces cardiometabolic risk factors.

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Furthermore, suggest the researchers, if the findings are replicated in a large-scale study, the bacteria could be sold commercially as dietary supplements by the year MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.

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